Transcriptional regulators of T cell exhaustion
Reported role across 47 papers on solid tumors, 2021–2025 · 6 representative studies shown
 
Chen
2024
Scott
2023
Beltra
2023
Giles
2022
Zebley
2024
Wang
2025
TOX
drives
drives
drives
drives
drives
drives
TCF1
restrains
restrains
restrains
restrains
context
restrains
NR4A
drives
drives
context
drives
drives
BATF
drives
restrains
drives
context
restrains
context
IRF4
drives
context
drives
restrains
drives
context
BLIMP-1
drives
drives
context
drives
restrains
T-bet
restrains
restrains
context
restrains
restrains
Drives exhaustion
Restrains exhaustion
Context-dependent
Not assessed
Source: PubMed